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Thyroid, liver, ovaries functioning is so very much interlinked.
Thyroid hormones help the liver with fat metabolism.
Liver in turn converts inactive T4 to active T3. And also creates proteins that act like a boat to carry thyroid hormones through the blood to the target tissues.
Healthy thyroid supports healthy liver function and vice versa.
T3 and T4 help liver to produce SHBG which binds to estrogen, progesterone and testosterone.
Insulin inhibits SHBG production. So Insulin resistance has a direct impact on menstrual cycle.
Cortisol impacts SHBG production and also reduces binding affinity of SHBG. Thus chronic stress impacts menstrual cycle.
LDL cholesterol is converted to Progesterone. Thus Hypothyroidism affects metabolism and uterus lining required within menstrual cycle.
Cortisol can act as a competitive antagonist of progesterone, meaning it can bind to the same receptors as progesterone and block its effects.
High cortisol
- Increases androgens (hirtuism)
- Reduces estrogen and progesterone (menstrual cycle issues, which also affects health of skin, bones and blood vessels)
- Inhibits SHBG production
- Reduces binding affinity of SHBG.
- Binds to progesterone receptors and blocks progesterone effects on the body. (Fertility issues)
- Leads to insulin resistance (Type 2 diabetes)
- increased insulin in turn inhibits SHBG causing a vicious loop
- causes increase in amount of fat stored in liver cells leading to NAFLD/MASLD
Effective ways to adress chronic stress:
- Diaphragmatic breathing (directly lowers cortisol level)
- somatic work - BCST, SE, Dance for safe embodiment
- music (Tones vagus nerve)
- Breathwork